Anti-PR3-ANCA associated vasculitis with rapidly progressive (crescentic) glomerulonephritis: Case report
Nayelhi Vanessa Mora Ponce- Gonzalo Andre Banchón Macias
- Rafael Ignacio López Martínez
- José Maximiliano Martínez Pérez
Published 2024-09-25
Keywords
- Anti-Neutrophil Cytoplasmic Antibodies,
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis,
- Granulomatosis with Polyangiitis,
- Glomerulonephritis
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Abstract
This is a case report of a 61-year-old male patient who came to the emergency room with one week of dyspnea on minimal exertion, dysphonia, chest pain, and fatigue, accompanied by weight loss in the last 3 months. Laboratory tests showed normocytic normochromic anemia, leukocytosis with neutrophilia, thrombocytosis, creatinine of 10.1 mg/dL, high CRP, proteinuria, and hematuria. Renal biopsy reveals pauci-immune (“crescentic”) extracapillary proliferative glomerulonephritis, labeling the diagnosis as Anti-PR3-ANCA-associated vasculitis with rapidly progressive glomerulonephritis. Induction and maintenance therapy are managed with intravenous rituximab and corticosteroids.